1mvf
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1mvf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVF FirstGlance]. <br> | <table><tr><td colspan='2'>[[1mvf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1MVF FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MazE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MazE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mvf RCSB], [http://www.ebi.ac.uk/pdbsum/1mvf PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1mvf RCSB], [http://www.ebi.ac.uk/pdbsum/1mvf PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CHPR_ECOLI CHPR_ECOLI]] Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that binds to the MazF mRNA interferase toxin and neutralizes its endoribonuclease activity. Is considered to be an 'addiction' molecule as the cell will die in its absence. The endoribonuclease activity (MazF, a toxin) is inhibited by the labile cognate antitoxin MazE. Toxicity results when the levels of MazE decrease in the cell, leading to mRNA degradation. This effect can be rescued by expression of MazE, but after 6 hours in rich medium the overexpression of MazF leads to programmed cell death. Cell growth and viability are not affected when MazF and MazE are coexpressed. Both MazE and MazE-MazF bind to the promoter region of the mazE-mazF operon to inhibit their transcription.<ref>PMID:8650219</ref> <ref>PMID:12123459</ref> <ref>PMID:15576778</ref> <ref>PMID:19707553</ref> Cell death governed by the MazE-MazF and DinJ-YafQ TA modules seems to play a role in biofilm formation, while MazE-MazF is also implicated in cell death in liquid media.<ref>PMID:8650219</ref> <ref>PMID:12123459</ref> <ref>PMID:15576778</ref> <ref>PMID:19707553</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Camelus dromedarius]] | [[Category: Camelus dromedarius]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Engelberg-Kulka, H | + | [[Category: Engelberg-Kulka, H]] |
| - | [[Category: Glaser, G | + | [[Category: Glaser, G]] |
| - | [[Category: Laeremans, T | + | [[Category: Laeremans, T]] |
| - | [[Category: Lah, J | + | [[Category: Lah, J]] |
| - | [[Category: Loris, R | + | [[Category: Loris, R]] |
| - | [[Category: Marianovsky, I | + | [[Category: Marianovsky, I]] |
| - | [[Category: Muyldermans, S | + | [[Category: Muyldermans, S]] |
| - | [[Category: Wyns, L | + | [[Category: Wyns, L]] |
[[Category: Addiction antidote]] | [[Category: Addiction antidote]] | ||
[[Category: Camel antibody]] | [[Category: Camel antibody]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
[[Category: Plasmid addiction]] | [[Category: Plasmid addiction]] | ||
Revision as of 21:32, 24 December 2014
MazE addiction antidote
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