4e0q
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e0q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e0q RCSB], [http://www.ebi.ac.uk/pdbsum/4e0q PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e0q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e0q RCSB], [http://www.ebi.ac.uk/pdbsum/4e0q PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CSN6_DROME CSN6_DROME]] Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.<ref>PMID:12737805</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 21:45, 24 December 2014
Crystal structure of MPN domain from COP9 signalosome
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