3q93
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q93 RCSB], [http://www.ebi.ac.uk/pdbsum/3q93 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q93 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q93 RCSB], [http://www.ebi.ac.uk/pdbsum/3q93 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref> | ||
==See Also== | ==See Also== | ||
*[[7%2C8-dihydro-8-oxoguanine triphosphatase|7%2C8-dihydro-8-oxoguanine triphosphatase]] | *[[7%2C8-dihydro-8-oxoguanine triphosphatase|7%2C8-dihydro-8-oxoguanine triphosphatase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 22:05, 24 December 2014
Crystal Structure of Human 8-oxo-dGTPase (MTH1)
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Categories: Homo sapiens | Arrowsmith, C H | Berg, S Van Der | Berglund, H | Bountra, C | Collins, R | Edwards, A M | Ekblad, T | Flodin, S | Flores, A | Graslund, S | Hammarstrom, M | Johansson, I | Karlberg, T | Kol, S | Kotenyova, T | Kouznetsova, E | Moche, M | Nordlund, P | Nyman, T | Persson, C | Structural genomic | Schuler, H | Schutz, P | Siponen, M I | Thorsell, A G | Tresaugues, L | Wahlberg, E | Weigelt, J | Welin, M | Hydrolase | Magnesium binding | Mutt-like | Nudix | Sgc
