2m5y
From Proteopedia
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| - | + | ==Solution Structure of the C-terminal domain of RV0431== | |
| - | + | <StructureSection load='2m5y' size='340' side='right' caption='[[2m5y]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[2m5y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M5Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M5Y FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m5y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m5y RCSB], [http://www.ebi.ac.uk/pdbsum/2m5y PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator." | ||
| - | + | Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.,Rath P, Huang C, Wang T, Wang T, Li H, Prados-Rosales R, Elemento O, Casadevall A, Nathan CF Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4790-7. doi:, 10.1073/pnas.1320118110. Epub 2013 Nov 18. PMID:24248369<ref>PMID:24248369</ref> | |
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| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: Huang, C | + | == References == |
| - | [[Category: Li, H | + | <references/> |
| - | [[Category: Wang, T | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Huang, C]] | ||
| + | [[Category: Li, H]] | ||
| + | [[Category: Wang, T]] | ||
[[Category: Unknown function]] | [[Category: Unknown function]] | ||
Revision as of 22:08, 24 December 2014
Solution Structure of the C-terminal domain of RV0431
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