4ehr
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ehr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EHR FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ehr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EHR FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0Q5:4-[5-BUTYL-3-(HYDROXYMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL]-3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLCARBONYL)-N-{[2-(TRIMETHYLSILYL)ETHYL]SULFONYL}BENZAMIDE'>0Q5</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0Q5:4-[5-BUTYL-3-(HYDROXYMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL]-3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLCARBONYL)-N-{[2-(TRIMETHYLSILYL)ETHYL]SULFONYL}BENZAMIDE'>0Q5</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ehr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ehr RCSB], [http://www.ebi.ac.uk/pdbsum/4ehr PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ehr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ehr RCSB], [http://www.ebi.ac.uk/pdbsum/4ehr PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Banfi, P | + | [[Category: Banfi, P]] |
| - | [[Category: Borzilleri, R M | + | [[Category: Borzilleri, R M]] |
| - | [[Category: Cai, Z | + | [[Category: Cai, Z]] |
| - | [[Category: Galvani, A | + | [[Category: Galvani, A]] |
| - | [[Category: Lippy, J | + | [[Category: Lippy, J]] |
| - | [[Category: Lombardo, L J | + | [[Category: Lombardo, L J]] |
| - | [[Category: Menichincheri, M | + | [[Category: Menichincheri, M]] |
| - | [[Category: Modugno, M | + | [[Category: Modugno, M]] |
| - | [[Category: Naglich, J | + | [[Category: Naglich, J]] |
| - | [[Category: Penhallow, B | + | [[Category: Penhallow, B]] |
| - | [[Category: Perez, H L | + | [[Category: Perez, H L]] |
| - | [[Category: Sack, J | + | [[Category: Sack, J]] |
| - | [[Category: Schmidt, R J | + | [[Category: Schmidt, R J]] |
| - | [[Category: Schroeder, G M | + | [[Category: Schroeder, G M]] |
| - | [[Category: Tebben, A | + | [[Category: Tebben, A]] |
| - | [[Category: Wei, D | + | [[Category: Wei, D]] |
| - | [[Category: Yan, C | + | [[Category: Yan, C]] |
| - | [[Category: Zhang, L | + | [[Category: Zhang, L]] |
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Bcl-2 family]] | [[Category: Bcl-2 family]] | ||
[[Category: Programmed cell death]] | [[Category: Programmed cell death]] | ||
Revision as of 22:09, 24 December 2014
Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide
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Categories: Homo sapiens | Banfi, P | Borzilleri, R M | Cai, Z | Galvani, A | Lippy, J | Lombardo, L J | Menichincheri, M | Modugno, M | Naglich, J | Penhallow, B | Perez, H L | Sack, J | Schmidt, R J | Schroeder, G M | Tebben, A | Wei, D | Yan, C | Zhang, L | Apoptosis | Bcl-2 family | Programmed cell death
