2mbc
From Proteopedia
(Difference between revisions)
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| - | + | ==Solution Structure of human holo-PRL-3 in complex with vanadate== | |
| - | + | <StructureSection load='2mbc' size='340' side='right' caption='[[2mbc]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[2mbc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MBC FirstGlance]. <br> |
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1v3a|1v3a]], [[1r6h|1r6h]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTP4A3, PRL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mbc RCSB], [http://www.ebi.ac.uk/pdbsum/2mbc PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/TP4A3_HUMAN TP4A3_HUMAN]] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.<ref>PMID:11355880</ref> <ref>PMID:12782572</ref> | [[http://www.uniprot.org/uniprot/TP4A3_HUMAN TP4A3_HUMAN]] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.<ref>PMID:11355880</ref> <ref>PMID:12782572</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Dual specificity phosphatase|Dual specificity phosphatase]] |
| - | + | *[[Tyrosine phosphatase|Tyrosine phosphatase]] | |
| - | == | + | == References == |
| - | <references | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein-tyrosine-phosphatase]] | [[Category: Protein-tyrosine-phosphatase]] | ||
| - | [[Category: Jeon, Y H | + | [[Category: Jeon, Y H]] |
| - | [[Category: Jeong, K | + | [[Category: Jeong, K]] |
| - | [[Category: Jin, B | + | [[Category: Jin, B]] |
| - | [[Category: Kang, D | + | [[Category: Kang, D]] |
| - | [[Category: Kim, E | + | [[Category: Kim, E]] |
| - | [[Category: Kim, J | + | [[Category: Kim, J]] |
| - | [[Category: Kim, Y | + | [[Category: Kim, Y]] |
| - | [[Category: Lee, C | + | [[Category: Lee, C]] |
| - | [[Category: Shin, S | + | [[Category: Shin, S]] |
[[Category: Holo-prl-3]] | [[Category: Holo-prl-3]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Vanadate]] | [[Category: Vanadate]] | ||
Revision as of 22:13, 24 December 2014
Solution Structure of human holo-PRL-3 in complex with vanadate
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Categories: Homo sapiens | Protein-tyrosine-phosphatase | Jeon, Y H | Jeong, K | Jin, B | Kang, D | Kim, E | Kim, J | Kim, Y | Lee, C | Shin, S | Holo-prl-3 | Hydrolase | Vanadate
