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4bvc
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bvc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BVC FirstGlance]. <br> | <table><tr><td colspan='2'>[[4bvc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BVC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BVC FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BV5:3-(4-PIPERIDYL)-N-[2-(TRIFLUOROMETHOXY)PHENYL]SULFONYL-PROPANAMIDE'>BV5</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BV5:3-(4-PIPERIDYL)-N-[2-(TRIFLUOROMETHOXY)PHENYL]SULFONYL-PROPANAMIDE'>BV5</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bv5|4bv5]], [[4bv7|4bv7]], [[4bvd|4bvd]], [[4bvv|4bvv]], [[4bvw|4bvw]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bv5|4bv5]], [[4bv7|4bv7]], [[4bvd|4bvd]], [[4bvv|4bvv]], [[4bvw|4bvw]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bvc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bvc RCSB], [http://www.ebi.ac.uk/pdbsum/4bvc PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bvc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bvc RCSB], [http://www.ebi.ac.uk/pdbsum/4bvc PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/APOA_HUMAN APOA_HUMAN]] Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.<ref>PMID:2531657</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Althage, M | + | [[Category: Althage, M]] |
| - | [[Category: Andersson, G M.K | + | [[Category: Andersson, G M.K]] |
| - | [[Category: Antonsson, T | + | [[Category: Antonsson, T]] |
| - | [[Category: Blaho, S | + | [[Category: Blaho, S]] |
| - | [[Category: Bodin, C | + | [[Category: Bodin, C]] |
| - | [[Category: Bostrom, J | + | [[Category: Bostrom, J]] |
| - | [[Category: Chen, Y | + | [[Category: Chen, Y]] |
| - | [[Category: Dahlen, A | + | [[Category: Dahlen, A]] |
| - | [[Category: Eriksson, P O | + | [[Category: Eriksson, P O]] |
| - | [[Category: Evertsson, E | + | [[Category: Evertsson, E]] |
| - | [[Category: Fex, T | + | [[Category: Fex, T]] |
| - | [[Category: Fjellstrom, O | + | [[Category: Fjellstrom, O]] |
| - | [[Category: Gustafsson, D | + | [[Category: Gustafsson, D]] |
| - | [[Category: Hallberg, C | + | [[Category: Hallberg, C]] |
| - | [[Category: Hicks, R | + | [[Category: Hicks, R]] |
| - | [[Category: Jarkvist, E | + | [[Category: Jarkvist, E]] |
| - | [[Category: Johansson, C | + | [[Category: Johansson, C]] |
| - | [[Category: Kalies, I | + | [[Category: Kalies, I]] |
| - | [[Category: Kang, D | + | [[Category: Kang, D]] |
| - | [[Category: Karlsson, B Svalstedt | + | [[Category: Karlsson, B Svalstedt]] |
| - | [[Category: Kartberg, F | + | [[Category: Kartberg, F]] |
| - | [[Category: Knecht, W | + | [[Category: Knecht, W]] |
| - | [[Category: Legnehed, A | + | [[Category: Legnehed, A]] |
| - | [[Category: Lindqvist, A M | + | [[Category: Lindqvist, A M]] |
| - | [[Category: Martinsson, S A | + | [[Category: Martinsson, S A]] |
| - | [[Category: Moberg, A | + | [[Category: Moberg, A]] |
| - | [[Category: Petersson, A U | + | [[Category: Petersson, A U]] |
| - | [[Category: Ridderstrom, M | + | [[Category: Ridderstrom, M]] |
| - | [[Category: Sandmark, J | + | [[Category: Sandmark, J]] |
| - | [[Category: Thelin, A | + | [[Category: Thelin, A]] |
| - | [[Category: Tigerstrom, A | + | [[Category: Tigerstrom, A]] |
| - | [[Category: Vinblad, J | + | [[Category: Vinblad, J]] |
| - | [[Category: Xu, B | + | [[Category: Xu, B]] |
[[Category: Cardiovascular disease]] | [[Category: Cardiovascular disease]] | ||
[[Category: Drug discovery]] | [[Category: Drug discovery]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Optical biosensor]] | [[Category: Optical biosensor]] | ||
Revision as of 22:25, 24 December 2014
Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.
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Categories: Althage, M | Andersson, G M.K | Antonsson, T | Blaho, S | Bodin, C | Bostrom, J | Chen, Y | Dahlen, A | Eriksson, P O | Evertsson, E | Fex, T | Fjellstrom, O | Gustafsson, D | Hallberg, C | Hicks, R | Jarkvist, E | Johansson, C | Kalies, I | Kang, D | Karlsson, B Svalstedt | Kartberg, F | Knecht, W | Legnehed, A | Lindqvist, A M | Martinsson, S A | Moberg, A | Petersson, A U | Ridderstrom, M | Sandmark, J | Thelin, A | Tigerstrom, A | Vinblad, J | Xu, B | Cardiovascular disease | Drug discovery | Hydrolase | Optical biosensor
