2eo6
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2eo6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EO6 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2eo6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EO6 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Blnk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Blnk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eo6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eo6 RCSB], [http://www.ebi.ac.uk/pdbsum/2eo6 PDBsum], [http://www.topsan.org/Proteins/RSGI/2eo6 TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eo6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2eo6 RCSB], [http://www.ebi.ac.uk/pdbsum/2eo6 PDBsum], [http://www.topsan.org/Proteins/RSGI/2eo6 TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BLNK_MOUSE BLNK_MOUSE]] Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.<ref>PMID:9705962</ref> <ref>PMID:12761551</ref> <ref>PMID:18369315</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 16: | Line 18: | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Hayashi, F | + | [[Category: Hayashi, F]] |
| - | [[Category: Kurosaki, C | + | [[Category: Kurosaki, C]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Sano, R | + | [[Category: Sano, R]] |
| - | [[Category: Yokoyama, S | + | [[Category: Yokoyama, S]] |
| - | [[Category: Yoshida, M | + | [[Category: Yoshida, M]] |
[[Category: B-cell adapter containing sh2 domain protein]] | [[Category: B-cell adapter containing sh2 domain protein]] | ||
[[Category: B-cell adapter containing src homology 2 domain protein]] | [[Category: B-cell adapter containing src homology 2 domain protein]] | ||
| Line 31: | Line 35: | ||
[[Category: National project on protein structural and functional analyse]] | [[Category: National project on protein structural and functional analyse]] | ||
[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
| - | [[Category: Riken structural genomics/proteomics initiative]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
[[Category: Sh2]] | [[Category: Sh2]] | ||
| Line 37: | Line 40: | ||
[[Category: Slp-65]] | [[Category: Slp-65]] | ||
[[Category: Src homology 2 domain-containing leukocyte protein of 65 kda]] | [[Category: Src homology 2 domain-containing leukocyte protein of 65 kda]] | ||
| - | [[Category: Structural genomic]] | ||
Revision as of 22:26, 24 December 2014
Solution structure of the SH2 domain from mouse B-cell linker protein BLNK
| |||||||||||
Categories: Mus musculus | Hayashi, F | Kurosaki, C | Structural genomic | Sano, R | Yokoyama, S | Yoshida, M | B-cell adapter containing sh2 domain protein | B-cell adapter containing src homology 2 domain protein | Cytoplasmic adapter protein | Lymphocyte antigen 57 | National project on protein structural and functional analyse | Nppsfa | Rsgi | Sh2 | Signaling protein | Slp-65 | Src homology 2 domain-containing leukocyte protein of 65 kda
