2m1r
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m1r RCSB], [http://www.ebi.ac.uk/pdbsum/2m1r PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2m1r RCSB], [http://www.ebi.ac.uk/pdbsum/2m1r PDBsum]</span></td></tr> | ||
</table> | </table> | ||
+ | == Function == | ||
+ | [[http://www.uniprot.org/uniprot/ING4_HUMAN ING4_HUMAN]] Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).<ref>PMID:12750254</ref> <ref>PMID:15251430</ref> <ref>PMID:15029197</ref> <ref>PMID:15528276</ref> <ref>PMID:15897452</ref> <ref>PMID:16387653</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
- | [[Category: Blanco, F J | + | [[Category: Blanco, F J]] |
[[Category: Gene regulation]] | [[Category: Gene regulation]] | ||
[[Category: Ing4]] | [[Category: Ing4]] | ||
[[Category: Phd]] | [[Category: Phd]] | ||
[[Category: Transcription]] | [[Category: Transcription]] |
Revision as of 22:29, 24 December 2014
PHD domain of ING4 N214D mutant
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Categories: Homo sapiens | Blanco, F J | Gene regulation | Ing4 | Phd | Transcription