2a1e

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[[Image:2a1e.gif|left|200px]]<br /><applet load="2a1e" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2a1e.gif|left|200px]]
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caption="2a1e, resolution 1.30&Aring;" />
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'''High resolution structure of HIV-1 PR with TS-126'''<br />
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{{Structure
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|PDB= 2a1e |SIZE=350|CAPTION= <scene name='initialview01'>2a1e</scene>, resolution 1.30&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IPF:N-ACETYLTRYPTOPHYL-N~1~-{3-[1-(N-ACETYLTRYPTOPHYLVALYL)PYRROLIDIN-2-YL]-1-BENZYL-2,3-DIHYDROXYPROPYL}VALINAMIDE'>IPF</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16]
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|GENE= GAG-POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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}}
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'''High resolution structure of HIV-1 PR with TS-126'''
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==About this Structure==
==About this Structure==
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2A1E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=ACT:'>ACT</scene>, <scene name='pdbligand=IPF:'>IPF</scene>, <scene name='pdbligand=DMS:'>DMS</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A1E OCA].
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2A1E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A1E OCA].
==Reference==
==Reference==
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A potent HIV protease inhibitor identified in an epimeric mixture by high-resolution protein crystallography., Geremia S, Demitri N, Wuerges J, Benedetti F, Berti F, Tell G, Randaccio L, ChemMedChem. 2006 Feb;1(2):186-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16892350 16892350]
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A potent HIV protease inhibitor identified in an epimeric mixture by high-resolution protein crystallography., Geremia S, Demitri N, Wuerges J, Benedetti F, Berti F, Tell G, Randaccio L, ChemMedChem. 2006 Feb;1(2):186-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16892350 16892350]
[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: stereoisomer]]
[[Category: stereoisomer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:22:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:44:17 2008''

Revision as of 13:44, 20 March 2008

Image:2a1e.gif


PDB ID 2a1e

Drag the structure with the mouse to rotate
, resolution 1.30Å
Ligands: , , , , and
Gene: GAG-POL (Human immunodeficiency virus 1)
Activity: HIV-1 retropepsin, with EC number 3.4.23.16
Coordinates: save as pdb, mmCIF, xml



High resolution structure of HIV-1 PR with TS-126


About this Structure

2A1E is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

A potent HIV protease inhibitor identified in an epimeric mixture by high-resolution protein crystallography., Geremia S, Demitri N, Wuerges J, Benedetti F, Berti F, Tell G, Randaccio L, ChemMedChem. 2006 Feb;1(2):186-8. PMID:16892350

Page seeded by OCA on Thu Mar 20 15:44:17 2008

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