2h6q
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2h6q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H6Q FirstGlance]. <br> | <table><tr><td colspan='2'>[[2h6q]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H6Q FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2co0|2co0]], [[2h6n|2h6n]], [[2h68|2h68]], [[2h6k|2h6k]], [[2cnx|2cnx]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2co0|2co0]], [[2h6n|2h6n]], [[2h68|2h68]], [[2h6k|2h6k]], [[2cnx|2cnx]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h6q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h6q RCSB], [http://www.ebi.ac.uk/pdbsum/2h6q PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h6q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h6q RCSB], [http://www.ebi.ac.uk/pdbsum/2h6q PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 31: | Line 33: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Allis, C D | + | [[Category: Allis, C D]] |
| - | [[Category: Graybosch, D M | + | [[Category: Graybosch, D M]] |
| - | [[Category: Li, H | + | [[Category: Li, H]] |
| - | [[Category: Patel, D J | + | [[Category: Patel, D J]] |
| - | [[Category: Ruthenburg, A J | + | [[Category: Ruthenburg, A J]] |
| - | [[Category: Verdine, G L | + | [[Category: Verdine, G L]] |
| - | [[Category: Wang, W K | + | [[Category: Wang, W K]] |
[[Category: Gene regulation]] | [[Category: Gene regulation]] | ||
[[Category: Wdr5 wd40 wd-repeat histone h3 modification mll set chromatin]] | [[Category: Wdr5 wd40 wd-repeat histone h3 modification mll set chromatin]] | ||
Revision as of 22:41, 24 December 2014
Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex
| |||||||||||
