1nci
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1nci]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The March 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Cadherin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_3 10.2210/rcsb_pdb/mom_2008_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NCI FirstGlance]. <br> | <table><tr><td colspan='2'>[[1nci]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The March 2008 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Cadherin'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2008_3 10.2210/rcsb_pdb/mom_2008_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NCI FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IUM:URANYL+(VI)+ION'>IUM</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IUM:URANYL+(VI)+ION'>IUM</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nci OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nci RCSB], [http://www.ebi.ac.uk/pdbsum/1nci PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nci OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1nci RCSB], [http://www.ebi.ac.uk/pdbsum/1nci PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CADH2_MOUSE CADH2_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.<ref>PMID:11433297</ref> <ref>PMID:17988630</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Als-Nielsen, J | + | [[Category: Als-Nielsen, J]] |
| - | [[Category: Colman, D R | + | [[Category: Colman, D R]] |
| - | [[Category: Fannon, A M | + | [[Category: Fannon, A M]] |
| - | [[Category: Grubel, G | + | [[Category: Grubel, G]] |
| - | [[Category: Hendrickson, W A | + | [[Category: Hendrickson, W A]] |
| - | [[Category: Kwong, P D | + | [[Category: Kwong, P D]] |
| - | [[Category: Legrand, J F | + | [[Category: Legrand, J F]] |
| - | [[Category: Lehmann, M S | + | [[Category: Lehmann, M S]] |
| - | [[Category: Shapiro, L | + | [[Category: Shapiro, L]] |
| - | [[Category: Thompson, A | + | [[Category: Thompson, A]] |
| - | + | ||
[[Category: Cell adhesion protein]] | [[Category: Cell adhesion protein]] | ||
Revision as of 22:42, 24 December 2014
STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS
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