3rhy

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3rhy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RHY FirstGlance]. <br>
<table><tr><td colspan='2'>[[3rhy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RHY FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HM3:(4-CHLOROPYRIDIN-2-YL)METHANOL'>HM3</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HM3:(4-CHLOROPYRIDIN-2-YL)METHANOL'>HM3</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h70|1h70]], [[3bpb|3bpb]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h70|1h70]], [[3bpb|3bpb]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA1195 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA1195 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dimethylargininase Dimethylargininase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.18 3.5.3.18] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dimethylargininase Dimethylargininase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.18 3.5.3.18] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rhy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rhy RCSB], [http://www.ebi.ac.uk/pdbsum/3rhy PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rhy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rhy RCSB], [http://www.ebi.ac.uk/pdbsum/3rhy PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/DDAH_PSEAE DDAH_PSEAE]] Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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On the Mechanism of Dimethylarginine Dimethylaminohydrolase Inactivation by 4-Halopyridines.,Johnson CM, Monzingo AF, Ke Z, Yoon DW, Linsky TW, Guo H, Robertus JD, Fast W J Am Chem Soc. 2011 Jun 1. PMID:21630706<ref>PMID:21630706</ref>
On the Mechanism of Dimethylarginine Dimethylaminohydrolase Inactivation by 4-Halopyridines.,Johnson CM, Monzingo AF, Ke Z, Yoon DW, Linsky TW, Guo H, Robertus JD, Fast W J Am Chem Soc. 2011 Jun 1. PMID:21630706<ref>PMID:21630706</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
== References ==
== References ==
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[[Category: Dimethylargininase]]
[[Category: Dimethylargininase]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Fast, W.]]
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[[Category: Fast, W]]
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[[Category: Guo, H.]]
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[[Category: Guo, H]]
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[[Category: Johnson, C M.]]
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[[Category: Johnson, C M]]
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[[Category: Ke, Z.]]
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[[Category: Ke, Z]]
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[[Category: Linsky, T W.]]
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[[Category: Linsky, T W]]
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[[Category: Monzingo, A F.]]
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[[Category: Monzingo, A F]]
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[[Category: Robertus, J D.]]
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[[Category: Robertus, J D]]
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[[Category: Yoon, D W.]]
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[[Category: Yoon, D W]]
[[Category: Enzyme adduct]]
[[Category: Enzyme adduct]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]

Revision as of 22:43, 24 December 2014

Crystal structure of the dimethylarginine dimethylaminohydrolase adduct with 4-chloro-2-hydroxymethylpyridine

3rhy, resolution 2.18Å

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