3rhy
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3rhy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RHY FirstGlance]. <br> | <table><tr><td colspan='2'>[[3rhy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RHY FirstGlance]. <br> | ||
- | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HM3:(4-CHLOROPYRIDIN-2-YL)METHANOL'>HM3</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HM3:(4-CHLOROPYRIDIN-2-YL)METHANOL'>HM3</scene></td></tr> |
- | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h70|1h70]], [[3bpb|3bpb]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h70|1h70]], [[3bpb|3bpb]]</td></tr> |
- | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA1195 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA1195 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr> |
- | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dimethylargininase Dimethylargininase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.18 3.5.3.18] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dimethylargininase Dimethylargininase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.18 3.5.3.18] </span></td></tr> |
- | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rhy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rhy RCSB], [http://www.ebi.ac.uk/pdbsum/3rhy PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rhy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rhy RCSB], [http://www.ebi.ac.uk/pdbsum/3rhy PDBsum]</span></td></tr> |
- | <table> | + | </table> |
+ | == Function == | ||
+ | [[http://www.uniprot.org/uniprot/DDAH_PSEAE DDAH_PSEAE]] Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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On the Mechanism of Dimethylarginine Dimethylaminohydrolase Inactivation by 4-Halopyridines.,Johnson CM, Monzingo AF, Ke Z, Yoon DW, Linsky TW, Guo H, Robertus JD, Fast W J Am Chem Soc. 2011 Jun 1. PMID:21630706<ref>PMID:21630706</ref> | On the Mechanism of Dimethylarginine Dimethylaminohydrolase Inactivation by 4-Halopyridines.,Johnson CM, Monzingo AF, Ke Z, Yoon DW, Linsky TW, Guo H, Robertus JD, Fast W J Am Chem Soc. 2011 Jun 1. PMID:21630706<ref>PMID:21630706</ref> | ||
- | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Dimethylargininase]] | [[Category: Dimethylargininase]] | ||
[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
- | [[Category: Fast, W | + | [[Category: Fast, W]] |
- | [[Category: Guo, H | + | [[Category: Guo, H]] |
- | [[Category: Johnson, C M | + | [[Category: Johnson, C M]] |
- | [[Category: Ke, Z | + | [[Category: Ke, Z]] |
- | [[Category: Linsky, T W | + | [[Category: Linsky, T W]] |
- | [[Category: Monzingo, A F | + | [[Category: Monzingo, A F]] |
- | [[Category: Robertus, J D | + | [[Category: Robertus, J D]] |
- | [[Category: Yoon, D W | + | [[Category: Yoon, D W]] |
[[Category: Enzyme adduct]] | [[Category: Enzyme adduct]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] |
Revision as of 22:43, 24 December 2014
Crystal structure of the dimethylarginine dimethylaminohydrolase adduct with 4-chloro-2-hydroxymethylpyridine
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