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1r17
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1r17]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R17 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R17 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1r17]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_epidermidis Staphylococcus epidermidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R17 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R17 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r19|1r19]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1r19|1r19]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SDRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1282 Staphylococcus epidermidis])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SDRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1282 Staphylococcus epidermidis])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r17 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r17 RCSB], [http://www.ebi.ac.uk/pdbsum/1r17 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r17 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r17 RCSB], [http://www.ebi.ac.uk/pdbsum/1r17 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SDRG_STAEP SDRG_STAEP]] Binds to the N-terminus of the B beta-chain of human fibrinogen and thereby interferes with thrombin cleavage and release of fibrinopeptide B, thus interfering with fibrin clot formation. This may hinder host defense against microbial infections.<ref>PMID:11371571</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Staphylococcus epidermidis]] | [[Category: Staphylococcus epidermidis]] | ||
| - | [[Category: Bowden, M G | + | [[Category: Bowden, M G]] |
| - | [[Category: Choe, D | + | [[Category: Choe, D]] |
| - | [[Category: Davis, S | + | [[Category: Davis, S]] |
| - | [[Category: Gurusiddappa, S | + | [[Category: Gurusiddappa, S]] |
| - | [[Category: Hook, M | + | [[Category: Hook, M]] |
| - | [[Category: Moore, D | + | [[Category: Moore, D]] |
| - | [[Category: Narayana, S V.L | + | [[Category: Narayana, S V.L]] |
| - | [[Category: Ponnuraj, K | + | [[Category: Ponnuraj, K]] |
| - | [[Category: Xu, Y | + | [[Category: Xu, Y]] |
[[Category: Cell adhesion]] | [[Category: Cell adhesion]] | ||
[[Category: Mscramm-ligand complex]] | [[Category: Mscramm-ligand complex]] | ||
[[Category: Sdrg]] | [[Category: Sdrg]] | ||
[[Category: Sdrg-fibrinopeptide complex]] | [[Category: Sdrg-fibrinopeptide complex]] | ||
Revision as of 22:48, 24 December 2014
Crystal Structure Analysis of S.epidermidis adhesin SdrG binding to Fibrinogen (adhesin-ligand complex)
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