1ixr

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ixr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IXR FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ixr]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IXR FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hqc|1hqc]], [[1ixs|1ixs]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hqc|1hqc]], [[1ixs|1ixs]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ruvA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]), ruvB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ruvA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus]), ruvB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ixr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ixr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ixr RCSB], [http://www.ebi.ac.uk/pdbsum/1ixr PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ixr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ixr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ixr RCSB], [http://www.ebi.ac.uk/pdbsum/1ixr PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RUVA_THET8 RUVA_THET8]] The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity). [[http://www.uniprot.org/uniprot/RUVB_THET8 RUVB_THET8]] The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvB is a Mg(2+)-dependent, DNA-dependent ATPase with an equal preference for supercoiled and linear duplex DNA. It can promote Holliday junction migration alone.<ref>PMID:10485292</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Adenosinetriphosphatase]]
[[Category: Adenosinetriphosphatase]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
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[[Category: Ariyoshi, M.]]
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[[Category: Ariyoshi, M]]
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[[Category: Fujiwara, Y.]]
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[[Category: Fujiwara, Y]]
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[[Category: Iwasaki, H.]]
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[[Category: Iwasaki, H]]
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[[Category: Mayanagi, K.]]
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[[Category: Mayanagi, K]]
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[[Category: Miyata, T.]]
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[[Category: Miyata, T]]
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[[Category: Morikawa, K.]]
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[[Category: Morikawa, K]]
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[[Category: Ohnishi, T.]]
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[[Category: Ohnishi, T]]
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[[Category: Oyama, T.]]
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[[Category: Oyama, T]]
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[[Category: Shinagawa, H.]]
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[[Category: Shinagawa, H]]
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[[Category: Tsuchiya, D.]]
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[[Category: Tsuchiya, D]]
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[[Category: Yamada, K.]]
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[[Category: Yamada, K]]
[[Category: Aaa-atpase domain]]
[[Category: Aaa-atpase domain]]
[[Category: Complex with nucleotide]]
[[Category: Complex with nucleotide]]

Revision as of 22:49, 24 December 2014

RuvA-RuvB complex

1ixr, resolution 3.30Å

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