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2k28

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2k28]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K28 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2k28]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K28 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K28 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CBX4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CBX4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k28 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k28 RCSB], [http://www.ebi.ac.uk/pdbsum/2k28 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k28 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k28 RCSB], [http://www.ebi.ac.uk/pdbsum/2k28 PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CBX4_HUMAN CBX4_HUMAN]] E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression.<ref>PMID:12679040</ref> <ref>PMID:16061479</ref> <ref>PMID:17018294</ref> <ref>PMID:21282530</ref> <ref>PMID:22825850</ref> Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.<ref>PMID:12679040</ref> <ref>PMID:16061479</ref> <ref>PMID:17018294</ref> <ref>PMID:21282530</ref> <ref>PMID:22825850</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards, A M]]
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[[Category: Fares, C.]]
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[[Category: Fares, C]]
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[[Category: Gutmanas, A.]]
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[[Category: Gutmanas, A]]
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[[Category: Kaustov, L.]]
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[[Category: Kaustov, L]]
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[[Category: Lemak, A.]]
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[[Category: Lemak, A]]
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[[Category: Loppnau, P.]]
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[[Category: Loppnau, P]]
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[[Category: Min, J.]]
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[[Category: Min, J]]
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[[Category: Quyang, H.]]
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[[Category: Quyang, H]]
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[[Category: Ravichandran, M.]]
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[[Category: Ravichandran, M]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
[[Category: Alpha/beta protein]]
[[Category: Alpha/beta protein]]
[[Category: Chromatin regulator]]
[[Category: Chromatin regulator]]
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[[Category: Repressor]]
[[Category: Repressor]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
 
[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
[[Category: Ubl conjugation pathway]]
[[Category: Ubl conjugation pathway]]

Revision as of 22:58, 24 December 2014

Solution NMR structure of the chromo domain of the chromobox protein homolog 4

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