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2i8b
From Proteopedia
(Difference between revisions)
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<StructureSection load='2i8b' size='340' side='right' caption='[[2i8b]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='2i8b' size='340' side='right' caption='[[2i8b]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2i8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I8B FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2i8b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Zaire_ebolavirus Zaire ebolavirus]. The October 2014 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ebola Virus Proteins'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2014_10 10.2210/rcsb_pdb/mom_2014_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I8B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I8B FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186538 Zaire ebolavirus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186538 Zaire ebolavirus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i8b RCSB], [http://www.ebi.ac.uk/pdbsum/2i8b PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i8b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i8b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2i8b RCSB], [http://www.ebi.ac.uk/pdbsum/2i8b PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VP30_EBOZM VP30_EBOZM]] Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA.<ref>PMID:12163572</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Ebola Virus Proteins]] | ||
| + | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Zaire ebolavirus]] | [[Category: Zaire ebolavirus]] | ||
| - | [[Category: Becker, S | + | [[Category: Becker, S]] |
| - | [[Category: Hartlieb, B | + | [[Category: Hartlieb, B]] |
| - | [[Category: Muziol, T M | + | [[Category: Muziol, T M]] |
| - | [[Category: Weissenhorn, W | + | [[Category: Weissenhorn, W]] |
[[Category: Rna binding]] | [[Category: Rna binding]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
[[Category: Vp30 ebola virus protein]] | [[Category: Vp30 ebola virus protein]] | ||
Revision as of 23:04, 24 December 2014
Crystal structure of the C-terminal domain of Ebola virus VP30
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