2a62

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[[Image:2a62.gif|left|200px]]<br /><applet load="2a62" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2a62.gif|left|200px]]
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caption="2a62, resolution 4.50&Aring;" />
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'''Crystal structure of mouse cadherin-8 EC1-3'''<br />
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{{Structure
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|PDB= 2a62 |SIZE=350|CAPTION= <scene name='initialview01'>2a62</scene>, resolution 4.50&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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|ACTIVITY=
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|GENE= Cdh8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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}}
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'''Crystal structure of mouse cadherin-8 EC1-3'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2A62 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A62 OCA].
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2A62 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A62 OCA].
==Reference==
==Reference==
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Type II cadherin ectodomain structures: implications for classical cadherin specificity., Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L, Cell. 2006 Mar 24;124(6):1255-68. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16564015 16564015]
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Type II cadherin ectodomain structures: implications for classical cadherin specificity., Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L, Cell. 2006 Mar 24;124(6):1255-68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16564015 16564015]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: homodimer]]
[[Category: homodimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:23:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:45:47 2008''

Revision as of 13:45, 20 March 2008

Image:2a62.gif


PDB ID 2a62

Drag the structure with the mouse to rotate
, resolution 4.50Å
Ligands:
Gene: Cdh8 (Mus musculus)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of mouse cadherin-8 EC1-3


Overview

Type I and II classical cadherins help to determine the adhesive specificities of animal cells. Crystal-structure determination of ectodomain regions from three type II cadherins reveals adhesive dimers formed by exchange of N-terminal beta strands between partner extracellular cadherin-1 (EC1) domains. These interfaces have two conserved tryptophan side chains that anchor each swapped strand, compared with one in type I cadherins, and include large hydrophobic regions unique to type II interfaces. The EC1 domains of type I and type II cadherins appear to encode cell adhesive specificity in vitro. Moreover, perturbation of motor neuron segregation with chimeric cadherins depends on EC1 domain identity, suggesting that this region, which includes the structurally defined adhesive interface, encodes type II cadherin functional specificity in vivo.

About this Structure

2A62 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Type II cadherin ectodomain structures: implications for classical cadherin specificity., Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L, Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015

Page seeded by OCA on Thu Mar 20 15:45:47 2008

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