This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3s2o
From Proteopedia
| Line 9: | Line 9: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s2o RCSB], [http://www.ebi.ac.uk/pdbsum/3s2o PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s2o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s2o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s2o RCSB], [http://www.ebi.ac.uk/pdbsum/3s2o PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 23:11, 24 December 2014
Fragment based discovery and optimisation of bace-1 inhibitors
| |||||||||||
Categories: Homo sapiens | Memapsin 2 | Barker, J | Godemann, R | Hallett, D | Kraemer, J | Madden, J | Smith, M A | Alzheimer's disease | Amyloid precursor protein secretase | Aspartic endopeptidase | Aspartic protease | Aspartyl protease | Base | Beta-secretase | Fluorescence polarisation | Fragment-based drug design | Glycoprotein | Hydrolase-hydrolase inhibitor complex | Protease | Transmembrane
