3bx4
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3bx4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BX4 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3bx4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BX4 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bx4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bx4 RCSB], [http://www.ebi.ac.uk/pdbsum/3bx4 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bx4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bx4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bx4 RCSB], [http://www.ebi.ac.uk/pdbsum/3bx4 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AGGB_CALRH AGGB_CALRH]] Elicits platelet aggregation by the binding to the C-type lectin domain family 1 member B (CLEC1B/CLEC2). Binding leads to tyrosine phosphorylation in the cytoplasmic tail of CLEC1B, which promotes the binding of spleen tyrosine kinase (Syk), subsequent activation of PLCgamma2, and platelet activation and aggregation. Binding to GPIbalpha (GP1BA) and alpha2/beta-1 (ITGA2/ITGB1) may also induce aggregation, but this is controversial.<ref>PMID:11287424</ref> <ref>PMID:9588185</ref> <ref>PMID:11728470</ref> <ref>PMID:7639679</ref> <ref>PMID:11453648</ref> <ref>PMID:11352922</ref> <ref>PMID:14630793</ref> <ref>PMID:16174766</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Calloselasma rhodostoma]] | [[Category: Calloselasma rhodostoma]] | ||
| - | [[Category: Clemetson, J M | + | [[Category: Clemetson, J M]] |
| - | [[Category: Clemetson, K J | + | [[Category: Clemetson, K J]] |
| - | [[Category: Emsley, J | + | [[Category: Emsley, J]] |
| - | [[Category: Hooley, E | + | [[Category: Hooley, E]] |
| - | [[Category: Navdaev, A | + | [[Category: Navdaev, A]] |
| - | [[Category: Pandey, A | + | [[Category: Pandey, A]] |
| - | [[Category: Papagrigoriou, E | + | [[Category: Papagrigoriou, E]] |
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 23:14, 24 December 2014
Crystal structure of the snake venom toxin aggretin
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