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1uf5
From Proteopedia
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| - | + | ==Crystal structure of C171A/V236A Mutant of N-carbamyl-D-amino acid amidohydrolase complexed with N-carbamyl-D-methionine== | |
| - | + | <StructureSection load='1uf5' size='340' side='right' caption='[[1uf5]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1uf5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_sp. Agrobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UF5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CDT:4-METHYLSULFANYL-2-UREIDO-BUTYRIC+ACID'>CDT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1erz|1erz]], [[1uf4|1uf4]], [[1uf7|1uf7]], [[1uf8|1uf8]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-carbamoyl-D-amino-acid_hydrolase N-carbamoyl-D-amino-acid hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.77 3.5.1.77] </span></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uf5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uf5 RCSB], [http://www.ebi.ac.uk/pdbsum/1uf5 PDBsum]</span></td></tr> |
| - | [[1uf5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Agrobacterium_sp. Agrobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UF5 OCA]. | + | </table> |
| - | [[Category: Agrobacterium sp | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/DCAS_AGRSK DCAS_AGRSK]] The enzyme catalyzes the hydrolysis of N-carbamoyl-D-amino acids to the corresponding which are useful intermediates in the preparation of beta-lactam antibiotics. Industrial production of beta-lactam antibiotics is now being developed using this enzyme. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uf/1uf5_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Agrobacterium sp]] | ||
[[Category: N-carbamoyl-D-amino-acid hydrolase]] | [[Category: N-carbamoyl-D-amino-acid hydrolase]] | ||
| - | [[Category: Aoki, M | + | [[Category: Aoki, M]] |
| - | [[Category: Hashimoto, H | + | [[Category: Hashimoto, H]] |
| - | [[Category: Ikenaka, Y | + | [[Category: Ikenaka, Y]] |
| - | [[Category: Morikawa, H | + | [[Category: Morikawa, H]] |
| - | [[Category: Nakai, T | + | [[Category: Nakai, T]] |
| - | [[Category: Sato, M | + | [[Category: Sato, M]] |
| - | [[Category: Shimizu, T | + | [[Category: Shimizu, T]] |
| - | [[Category: Takahashi, S | + | [[Category: Takahashi, S]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 23:16, 24 December 2014
Crystal structure of C171A/V236A Mutant of N-carbamyl-D-amino acid amidohydrolase complexed with N-carbamyl-D-methionine
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