1tue
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1tue]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TUE FirstGlance]. <br> | <table><tr><td colspan='2'>[[1tue]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TUE FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=333761 Human papillomavirus type 18]), E2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=333761 Human papillomavirus type 18])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">E1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=333761 Human papillomavirus type 18]), E2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=333761 Human papillomavirus type 18])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tue OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tue RCSB], [http://www.ebi.ac.uk/pdbsum/1tue PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tue OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tue RCSB], [http://www.ebi.ac.uk/pdbsum/1tue PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VE1_HPV18 VE1_HPV18]] ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human papillomavirus type 18]] | [[Category: Human papillomavirus type 18]] | ||
| - | [[Category: Abbate, E A | + | [[Category: Abbate, E A]] |
| - | [[Category: Berger, J M | + | [[Category: Berger, J M]] |
| - | [[Category: Botchan, M R | + | [[Category: Botchan, M R]] |
[[Category: Aaa+ protein]] | [[Category: Aaa+ protein]] | ||
[[Category: E1e2 complex]] | [[Category: E1e2 complex]] | ||
Revision as of 23:31, 24 December 2014
The X-ray Structure of the Papillomavirus Helicase in Complex with its Molecular Matchmaker E2
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