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2a9i
From Proteopedia
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| - | [[Image:2a9i.gif|left|200px]] | + | [[Image:2a9i.gif|left|200px]] |
| - | + | ||
| - | '''Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain''' | + | {{Structure |
| + | |PDB= 2a9i |SIZE=350|CAPTION= <scene name='initialview01'>2a9i</scene>, resolution 1.70Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=MN:MANGANESE (II) ION'>MN</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] | ||
| + | |GENE= Irak4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | }} | ||
| + | |||
| + | '''Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2A9I is a [ | + | 2A9I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9I OCA]. |
==Reference== | ==Reference== | ||
| - | Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling., Lasker MV, Gajjar MM, Nair SK, J Immunol. 2005 Oct 1;175(7):4175-9. PMID:[http:// | + | Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling., Lasker MV, Gajjar MM, Nair SK, J Immunol. 2005 Oct 1;175(7):4175-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16177054 16177054] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
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[[Category: hexahelical bundle]] | [[Category: hexahelical bundle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:47:06 2008'' |
Revision as of 13:47, 20 March 2008
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| , resolution 1.70Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | Irak4 (Mus musculus) | ||||||
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Molecular Structure of the Interleukin-1 Receptor-Associated Kinase-4 Death Domain
Overview
IL-1R-associated kinase (IRAK) 4 is an essential component of innate immunity. IRAK-4 deficiency in mice and humans results in severe impairment of IL-1 and TLR signaling. We have solved the crystal structure for the death domain of Mus musculus IRAK-4 to 1.7 A resolution. This is the first glimpse of the structural details of a mammalian IRAK family member. The crystal structure reveals a six-helical bundle with a prominent loop, which among IRAKs and Pelle, a Drosophila homologue, is unique to IRAK-4. This highly structured loop contained between helices two and three, comprises an 11-aa stretch. Although innate immune domain recognition is thought to be very similar between Drosophila and mammals, this structural component points to a drastic difference. This structure can be used as a framework for future mutation and deletion studies and potential drug design.
About this Structure
2A9I is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling., Lasker MV, Gajjar MM, Nair SK, J Immunol. 2005 Oct 1;175(7):4175-9. PMID:16177054
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