4nqy

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4nqy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NQY FirstGlance]. <br>
<table><tr><td colspan='2'>[[4nqy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NQY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NQY FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kp1|4kp1]], [[4kp2|4kp2]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kp1|4kp1]], [[4kp2|4kp2]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nqy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nqy RCSB], [http://www.ebi.ac.uk/pdbsum/4nqy PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nqy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nqy RCSB], [http://www.ebi.ac.uk/pdbsum/4nqy PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/LEUC_METJA LEUC_METJA]] Enzyme with broad specificity that catalyzes reversible hydroxyacid isomerizations via dehydration/hydration reactions. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate, a step involved in leucine biosynthesis. Catalyzes the isomerization between 2-methylmalate and 3-methylmalate, via the formation of 2-methylmaleate (citraconate), a step involved in isoleucine biosynthesis. Also displays malease activity, i.e. catalyzes the hydration of maleate to form (R)-malate.<ref>PMID:17449626</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural characterization and comparison of the large subunits of IPM isomerase and homoaconitase from Methanococcus jannaschii.,Lee EH, Lee K, Hwang KY Acta Crystallogr D Biol Crystallogr. 2014 Apr 1;70(Pt 4):922-31. doi:, 10.1107/S1399004713033762. Epub 2014 Mar 19. PMID:24699638<ref>PMID:24699638</ref>
Structural characterization and comparison of the large subunits of IPM isomerase and homoaconitase from Methanococcus jannaschii.,Lee EH, Lee K, Hwang KY Acta Crystallogr D Biol Crystallogr. 2014 Apr 1;70(Pt 4):922-31. doi:, 10.1107/S1399004713033762. Epub 2014 Mar 19. PMID:24699638<ref>PMID:24699638</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hwang, K Y.]]
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[[Category: Hwang, K Y]]
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[[Category: Lee, E H.]]
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[[Category: Lee, E H]]
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[[Category: Lee, K.]]
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[[Category: Lee, K]]
[[Category: Alpha-beta sandwitch]]
[[Category: Alpha-beta sandwitch]]
[[Category: Cytosol]]
[[Category: Cytosol]]

Revision as of 23:47, 24 December 2014

The reduced form of MJ0499

4nqy, resolution 2.60Å

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