4nmh
From Proteopedia
(Difference between revisions)
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| - | + | ==11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one== | |
| - | + | <StructureSection load='4nmh' size='340' side='right' caption='[[4nmh]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[4nmh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NMH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NMH FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2KG:(4S)-4-(2-METHOXYPHENYL)-3,3-DIMETHYL-1-[3-(METHYLSULFONYL)PHENYL]AZETIDIN-2-ONE'>2KG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Hsd11b1, Hsd11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nmh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nmh RCSB], [http://www.ebi.ac.uk/pdbsum/4nmh PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/DHI1_MOUSE DHI1_MOUSE]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. | [[http://www.uniprot.org/uniprot/DHI1_MOUSE DHI1_MOUSE]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. | ||
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
[[Category: 11-beta-hydroxysteroid dehydrogenase]] | [[Category: 11-beta-hydroxysteroid dehydrogenase]] | ||
| - | [[Category: Augustin, M | + | [[Category: Lk3 transgenic mice]] |
| - | [[Category: Blake, C | + | [[Category: Augustin, M]] |
| - | [[Category: Ertan, A | + | [[Category: Blake, C]] |
| - | [[Category: Gerhardt, S | + | [[Category: Ertan, A]] |
| - | [[Category: Kilgour, E K | + | [[Category: Gerhardt, S]] |
| - | [[Category: Krapp, S | + | [[Category: Kilgour, E K]] |
| - | [[Category: McCoull, W | + | [[Category: Krapp, S]] |
| - | [[Category: Moore, J E | + | [[Category: McCoull, W]] |
| - | [[Category: Newcombe, N J | + | [[Category: Moore, J E]] |
| - | [[Category: Ogg, D J | + | [[Category: Newcombe, N J]] |
| - | [[Category: Packer, M J | + | [[Category: Ogg, D J]] |
| - | [[Category: Rees, A | + | [[Category: Packer, M J]] |
| - | [[Category: Revill, J | + | [[Category: Rees, A]] |
| - | [[Category: Scott, J S | + | [[Category: Revill, J]] |
| - | [[Category: Selmi, N | + | [[Category: Scott, J S]] |
| - | [[Category: Steinbacher, S | + | [[Category: Selmi, N]] |
| - | [[Category: Whittamore, P R.O | + | [[Category: Steinbacher, S]] |
| + | [[Category: Whittamore, P R.O]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | ||
Revision as of 23:48, 24 December 2014
11-beta-HSD1 in complex with a 3,3-Di-methyl-azetidin-2-one
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Categories: 11-beta-hydroxysteroid dehydrogenase | Lk3 transgenic mice | Augustin, M | Blake, C | Ertan, A | Gerhardt, S | Kilgour, E K | Krapp, S | McCoull, W | Moore, J E | Newcombe, N J | Ogg, D J | Packer, M J | Rees, A | Revill, J | Scott, J S | Selmi, N | Steinbacher, S | Whittamore, P R.O | Oxidoreductase | Oxidoreductase-oxidoreductase inhibitor complex
