4hbd
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hbd RCSB], [http://www.ebi.ac.uk/pdbsum/4hbd PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hbd RCSB], [http://www.ebi.ac.uk/pdbsum/4hbd PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KANK2_HUMAN KANK2_HUMAN]] Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus. May be involved in promotion of cell proliferation.<ref>PMID:17476305</ref> <ref>PMID:22371500</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 23:53, 24 December 2014
Crystal structure of KANK2 ankyrin repeats
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Categories: Homo sapiens | Arrowsmith, C H | Bakkouri, M El | Bountra, C | Cerovina, T | Edwards, A M | Min, J | Structural genomic | Tempel, W | Xu, C | Protein binding | Sgc
