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1ihb
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ihb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IHB FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ihb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IHB FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">P18-INK4C(INK6) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">P18-INK4C(INK6) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ihb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ihb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ihb RCSB], [http://www.ebi.ac.uk/pdbsum/1ihb PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ihb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ihb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ihb RCSB], [http://www.ebi.ac.uk/pdbsum/1ihb PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CDN2C_HUMAN CDN2C_HUMAN]] Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Marmorstein, R | + | [[Category: Marmorstein, R]] |
| - | [[Category: Ravichandran, V | + | [[Category: Ravichandran, V]] |
| - | [[Category: Swaminathan, K | + | [[Category: Swaminathan, K]] |
[[Category: Ankyrin repeat]] | [[Category: Ankyrin repeat]] | ||
[[Category: Cdk 4/6 inhibitor]] | [[Category: Cdk 4/6 inhibitor]] | ||
[[Category: Cell cycle inhibitor]] | [[Category: Cell cycle inhibitor]] | ||
Revision as of 23:57, 24 December 2014
CRYSTAL STRUCTURE OF P18-INK4C(INK6)
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