3lbj
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lbj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lbj RCSB], [http://www.ebi.ac.uk/pdbsum/3lbj PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lbj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lbj RCSB], [http://www.ebi.ac.uk/pdbsum/3lbj PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[MDM4|MDM4]] | *[[MDM4|MDM4]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 23:57, 24 December 2014
Structure of human MDMX protein in complex with a small molecule inhibitor
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Categories: Homo sapiens | Czarna, A | Holak, T A | Popowicz, G M | Wolf, S | Cell cycle | Inhibitor | Mdm2 | Mdmx | Nucleus | P53 | Zinc-finger
