2ygb
From Proteopedia
(Difference between revisions)
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<StructureSection load='2ygb' size='340' side='right' caption='[[2ygb]], [[Resolution|resolution]] 2.81Å' scene=''> | <StructureSection load='2ygb' size='340' side='right' caption='[[2ygb]], [[Resolution|resolution]] 2.81Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ygb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus_western_reserve Vaccinia virus western reserve]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGB OCA]. | + | <table><tr><td colspan='2'>[[2ygb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Vaccinia_virus_western_reserve Vaccinia virus western reserve]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YGB FirstGlance]. <br> |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ygb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ygb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ygb RCSB], [http://www.ebi.ac.uk/pdbsum/2ygb PDBsum]</span></td></tr> | |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ygb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ygb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ygb RCSB], [http://www.ebi.ac.uk/pdbsum/2ygb PDBsum]</span></td></tr> | + | </table> |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/REFR_VACCW REFR_VACCW]] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of A17 N-terminus. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Insights into the evolution of a complex virus from the crystal structure of vaccinia virus d13.,Bahar MW, Graham SC, Stuart DI, Grimes JM Structure. 2011 Jul 13;19(7):1011-20. PMID:21742267<ref>PMID:21742267</ref> | Insights into the evolution of a complex virus from the crystal structure of vaccinia virus d13.,Bahar MW, Graham SC, Stuart DI, Grimes JM Structure. 2011 Jul 13;19(7):1011-20. PMID:21742267<ref>PMID:21742267</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Vaccinia virus western reserve]] | [[Category: Vaccinia virus western reserve]] | ||
| - | [[Category: Bahar, M W | + | [[Category: Bahar, M W]] |
| - | [[Category: Graham, S C | + | [[Category: Graham, S C]] |
| - | [[Category: Grimes, J M | + | [[Category: Grimes, J M]] |
| - | [[Category: Stuart, D I | + | [[Category: Stuart, D I]] |
[[Category: Viral evolution]] | [[Category: Viral evolution]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 23:59, 24 December 2014
STRUCTURE OF VACCINIA VIRUS D13 SCAFFOLDING PROTEIN
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