1h6o

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h6o RCSB], [http://www.ebi.ac.uk/pdbsum/1h6o PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1h6o RCSB], [http://www.ebi.ac.uk/pdbsum/1h6o PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TERF1_HUMAN TERF1_HUMAN]] Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.<ref>PMID:16166375</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 00:22, 25 December 2014

DIMERISATION DOMAIN FROM HUMAN TRF1

1h6o, resolution 2.90Å

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