4crs

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{{STRUCTURE_4crs| PDB=4crs | SCENE= }}
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==Human Protein Kinase N2 (PKN2, PRKCL2) in complex with ATPgammaS==
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===Human Protein Kinase N2 (PKN2, PRKCL2) in complex with ATPgammaS===
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<StructureSection load='4crs' size='340' side='right' caption='[[4crs]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4crs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CRS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_kinase_C Protein kinase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.13 2.7.11.13] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4crs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4crs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4crs RCSB], [http://www.ebi.ac.uk/pdbsum/4crs PDBsum]</span></td></tr>
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</table>
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== Function ==
[[http://www.uniprot.org/uniprot/PKN2_HUMAN PKN2_HUMAN]] PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.<ref>PMID:9121475</ref> <ref>PMID:10226025</ref> <ref>PMID:10926925</ref> <ref>PMID:11781095</ref> <ref>PMID:11777936</ref> <ref>PMID:15364941</ref> <ref>PMID:17332740</ref> <ref>PMID:20188095</ref> <ref>PMID:20974804</ref> <ref>PMID:21754995</ref>
[[http://www.uniprot.org/uniprot/PKN2_HUMAN PKN2_HUMAN]] PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.<ref>PMID:9121475</ref> <ref>PMID:10226025</ref> <ref>PMID:10926925</ref> <ref>PMID:11781095</ref> <ref>PMID:11777936</ref> <ref>PMID:15364941</ref> <ref>PMID:17332740</ref> <ref>PMID:20188095</ref> <ref>PMID:20974804</ref> <ref>PMID:21754995</ref>
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==About this Structure==
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==See Also==
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[[4crs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CRS OCA].
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*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
[[Category: Protein kinase C]]
[[Category: Protein kinase C]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith, C]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Cocking, R.]]
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[[Category: Cocking, R]]
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[[Category: Cooper, C D.]]
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[[Category: Cooper, C D]]
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[[Category: Delft, F von.]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards, A M]]
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[[Category: Elkins, J M.]]
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[[Category: Elkins, J M]]
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[[Category: Knapp, S.]]
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[[Category: Knapp, S]]
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[[Category: Mathea, S.]]
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[[Category: Mathea, S]]
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[[Category: Newman, J A.]]
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[[Category: Newman, J A]]
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[[Category: Salah, E.]]
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[[Category: Salah, E]]
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[[Category: Shrestha, B.]]
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[[Category: Shrestha, B]]
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[[Category: Shrestha, L.]]
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[[Category: Shrestha, L]]
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[[Category: Szklarz, M.]]
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[[Category: Szklarz, M]]
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[[Category: Tallant, C.]]
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[[Category: Tallant, C]]
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[[Category: Tumber, A.]]
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[[Category: Tumber, A]]
[[Category: Agc]]
[[Category: Agc]]
[[Category: Pkn2]]
[[Category: Pkn2]]
[[Category: Prkcl2]]
[[Category: Prkcl2]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 00:40, 25 December 2014

Human Protein Kinase N2 (PKN2, PRKCL2) in complex with ATPgammaS

4crs, resolution 2.75Å

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