3q7j
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3q7j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q7J FirstGlance]. <br> | <table><tr><td colspan='2'>[[3q7j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q7J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q7J FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FBO:L-PHENYLALANYL-N6-[(BENZYLOXY)CARBONYL]-N1-HYDROXY-L-LYSINAMIDE'>FBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FBO:L-PHENYLALANYL-N6-[(BENZYLOXY)CARBONYL]-N1-HYDROXY-L-LYSINAMIDE'>FBO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">O93655, Ta0815, trf3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2303 Thermoplasma acidophilum])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">O93655, Ta0815, trf3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2303 Thermoplasma acidophilum])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q7j RCSB], [http://www.ebi.ac.uk/pdbsum/3q7j PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q7j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q7j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q7j RCSB], [http://www.ebi.ac.uk/pdbsum/3q7j PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TRF3_THEAC TRF3_THEAC]] Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development.,Su J, Wang Q, Feng J, Zhang C, Zhu D, Wei T, Xu W, Gu L Bioorg Med Chem. 2011 May 1;19(9):2991-6. Epub 2011 Mar 21. PMID:21493078<ref>PMID:21493078</ref> | Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development.,Su J, Wang Q, Feng J, Zhang C, Zhu D, Wei T, Xu W, Gu L Bioorg Med Chem. 2011 May 1;19(9):2991-6. Epub 2011 Mar 21. PMID:21493078<ref>PMID:21493078</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
| Line 20: | Line 22: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Thermoplasma acidophilum]] | [[Category: Thermoplasma acidophilum]] | ||
| - | [[Category: Feng, J | + | [[Category: Feng, J]] |
| - | [[Category: Gu, L | + | [[Category: Gu, L]] |
| - | [[Category: Su, J | + | [[Category: Su, J]] |
| - | [[Category: Wang, Q | + | [[Category: Wang, Q]] |
| - | [[Category: We, T | + | [[Category: We, T]] |
| - | [[Category: Xu, W | + | [[Category: Xu, W]] |
| - | [[Category: Zhang, C | + | [[Category: Zhang, C]] |
| - | [[Category: Zhu, D | + | [[Category: Zhu, D]] |
[[Category: Aminopeptidase]] | [[Category: Aminopeptidase]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
Revision as of 00:43, 25 December 2014
Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development
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