2ykd
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ykd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ykd RCSB], [http://www.ebi.ac.uk/pdbsum/2ykd PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ykd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ykd RCSB], [http://www.ebi.ac.uk/pdbsum/2ykd PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MATRX_HRSVA MATRX_HRSVA]] Has a crucial role in virus assembly and budding. The matrix interacts with the RNP complex and this association serves two functions: facilitate virion assembly and inhibit the viral transcriptase activity. Early in infection, M is localized to the nucleus and may inhibit host cell transcription. Later on, M can associate with lipid rafts supposely by interacting with the cytoskeleton and with the cytoplasmic tail of glycoprotein G. The binding of M to host membrane is stabilized by the surface expression of the viral glycoproteins. These interactions may allow virus formation by mediating association of the nucleocapsid with the nascent envelop.<ref>PMID:11907323</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 00:56, 25 December 2014
STRUCTURE OF THE MATRIX PROTEIN FROM HUMAN RESPIRATORY SYNCYTIAL VIRUS
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