2aoz

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[[Image:2aoz.gif|left|200px]]<br /><applet load="2aoz" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2aoz.gif|left|200px]]
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caption="2aoz, resolution 2.08&Aring;" />
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'''Crystal structure of the myotoxin-II from Atropoides nummifer venom'''<br />
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{{Structure
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|PDB= 2aoz |SIZE=350|CAPTION= <scene name='initialview01'>2aoz</scene>, resolution 2.08&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of the myotoxin-II from Atropoides nummifer venom'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2AOZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Atropoides_nummifer Atropoides nummifer] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AOZ OCA].
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2AOZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Atropoides_nummifer Atropoides nummifer]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AOZ OCA].
==Reference==
==Reference==
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Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom., Murakami MT, Melo CC, Angulo Y, Lomonte B, Arni RK, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt, 5):423-6. Epub 2006 Apr 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16682766 16682766]
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Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom., Murakami MT, Melo CC, Angulo Y, Lomonte B, Arni RK, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt, 5):423-6. Epub 2006 Apr 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16682766 16682766]
[[Category: Atropoides nummifer]]
[[Category: Atropoides nummifer]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: x-ray diffration]]
[[Category: x-ray diffration]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:29:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:52:08 2008''

Revision as of 13:52, 20 March 2008

Image:2aoz.gif


PDB ID 2aoz

Drag the structure with the mouse to rotate
, resolution 2.08Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the myotoxin-II from Atropoides nummifer venom


Overview

Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 angstroms resolution and the anion-binding site has been characterized.

About this Structure

2AOZ is a Single protein structure of sequence from Atropoides nummifer. Full crystallographic information is available from OCA.

Reference

Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom., Murakami MT, Melo CC, Angulo Y, Lomonte B, Arni RK, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt, 5):423-6. Epub 2006 Apr 12. PMID:16682766

Page seeded by OCA on Thu Mar 20 15:52:08 2008

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