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2aql
From Proteopedia
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| - | [[Image:2aql.gif|left|200px]] | + | [[Image:2aql.gif|left|200px]] |
| - | + | ||
| - | '''Crystal Structure of the MRG15 MRG domain''' | + | {{Structure |
| + | |PDB= 2aql |SIZE=350|CAPTION= <scene name='initialview01'>2aql</scene>, resolution 2.30Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= MORF4L1, MRG15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of the MRG15 MRG domain''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2AQL is a [ | + | 2AQL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AQL OCA]. |
==Reference== | ==Reference== | ||
| - | Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain., Bowman BR, Moure CM, Kirtane BM, Welschhans RL, Tominaga K, Pereira-Smith OM, Quiocho FA, Structure. 2006 Jan;14(1):151-8. PMID:[http:// | + | Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain., Bowman BR, Moure CM, Kirtane BM, Welschhans RL, Tominaga K, Pereira-Smith OM, Quiocho FA, Structure. 2006 Jan;14(1):151-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16407074 16407074] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: core binding domain]] | [[Category: core binding domain]] | ||
[[Category: dna binding]] | [[Category: dna binding]] | ||
| - | [[Category: helix | + | [[Category: helix hairpin]] |
[[Category: mrg domain]] | [[Category: mrg domain]] | ||
[[Category: recombinase]] | [[Category: recombinase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:52:41 2008'' |
Revision as of 13:52, 20 March 2008
| |||||||
| , resolution 2.30Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | MORF4L1, MRG15 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of the MRG15 MRG domain
Overview
The ubiquitous MRG/MORF family of proteins is involved in cell senescence, or the terminal loss of proliferative potential, a model for aging and tumor suppression at the cellular level. These proteins are defined by the approximately 20 kDa MRG domain that binds a plethora of transcriptional regulators and chromatin-remodeling factors, including the histone deacetylase transcriptional corepressor mSin3A and the novel nuclear protein PAM14, and they are also known components of the Tip60/NuA4 complex via interactions with the MRG binding protein (MRGBP). We present here the crystal structure of a prototypic MRG domain from human MRG15 whose core consists of two orthogonal helix hairpins. Despite the lack of sequence similarity, the core structure has surprisingly striking homology to a DNA-interacting domain of the tyrosine site-specific recombinases XerD, lambda integrase, and Cre. Site-directed mutagenesis studies based on the X-ray structure and bioinformatics identified key residues involved in the binding of PAM14 and MRGBP.
About this Structure
2AQL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain., Bowman BR, Moure CM, Kirtane BM, Welschhans RL, Tominaga K, Pereira-Smith OM, Quiocho FA, Structure. 2006 Jan;14(1):151-8. PMID:16407074
Page seeded by OCA on Thu Mar 20 15:52:41 2008
