4ram
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ram]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RAM FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ram]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RAM FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PNM:OPEN+FORM+-+PENICILLIN+G'>PNM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PNM:OPEN+FORM+-+PENICILLIN+G'>PNM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rkj|3rkj]], [[3rkk|3rkk]], [[3sbl|3sbl]], [[3sfp|3sfp]], [[3srx|3srx]], [[4gyq|4gyq]], [[4h0d|4h0d]], [[4hky|4hky]], [[4hl1|4hl1]], [[4gyu|4gyu]], [[4hl2|4hl2]], [[4raw|4raw]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3rkj|3rkj]], [[3rkk|3rkk]], [[3sbl|3sbl]], [[3sfp|3sfp]], [[3srx|3srx]], [[4gyq|4gyq]], [[4h0d|4h0d]], [[4hky|4hky]], [[4hl1|4hl1]], [[4gyu|4gyu]], [[4hl2|4hl2]], [[4raw|4raw]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ram FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ram OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ram RCSB], [http://www.ebi.ac.uk/pdbsum/4ram PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ram FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ram OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ram RCSB], [http://www.ebi.ac.uk/pdbsum/4ram PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Beta-lactamase]] | [[Category: Beta-lactamase]] | ||
| - | [[Category: Babnigg, G | + | [[Category: Babnigg, G]] |
| - | [[Category: Jedrzejczak, R | + | [[Category: Jedrzejczak, R]] |
| - | [[Category: Joachimiak, A | + | [[Category: Joachimiak, A]] |
| - | [[Category: Kim, Y | + | [[Category: Kim, Y]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors | + | [[Category: MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors]] |
| - | [[Category: Sacchettini, J | + | [[Category: Sacchettini, J]] |
| - | [[Category: Tesar, C | + | [[Category: Tesar, C]] |
[[Category: Alpha-beta-beta-alpha sandwich]] | [[Category: Alpha-beta-beta-alpha sandwich]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Hydrolase-antibiotic complex]] | [[Category: Hydrolase-antibiotic complex]] | ||
[[Category: Mcsg]] | [[Category: Mcsg]] | ||
| - | [[Category: Midwest center for structural genomic]] | ||
[[Category: Mtbi]] | [[Category: Mtbi]] | ||
[[Category: Psi-biology]] | [[Category: Psi-biology]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]] | [[Category: Structures of mtb proteins conferring susceptibility to known mtb inhibitor]] | ||
Revision as of 01:22, 25 December 2014
Crystal Structure of New Delhi Metallo-beta-Lactamase-1 Mutant M67V Complexed with Hydrolyzed Penicillin G
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Categories: Beta-lactamase | Babnigg, G | Jedrzejczak, R | Joachimiak, A | Kim, Y | Structural genomic | MTBI, Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors | Sacchettini, J | Tesar, C | Alpha-beta-beta-alpha sandwich | Hydrolase | Hydrolase-antibiotic complex | Mcsg | Mtbi | Psi-biology | Structures of mtb proteins conferring susceptibility to known mtb inhibitor
