3zxg

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[[Image:3zxg.png|left|200px]]
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==lysenin sphingomyelin complex==
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<StructureSection load='3zxg' size='340' side='right' caption='[[3zxg]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3zxg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Eisenia_fetida Eisenia fetida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZXG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0SM:TRIMETHYL-[2-[[(2S,3S)-2-(OCTADECANOYLAMINO)-3-OXIDANYL-BUTOXY]-OXIDANYL-PHOSPHORYL]OXYETHYL]AZANIUM'>0SM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3zx7|3zx7]], [[3zxd|3zxd]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zxg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zxg RCSB], [http://www.ebi.ac.uk/pdbsum/3zxg PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TXL_EISFO TXL_EISFO]] Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells. Has hemolytic activity. Is also cytotoxic to spermatozoa of some species of invertebrates and many species of vertebrates and to amphibian larvae, guinea pig polymorphonuclear leukocytes, chicken fibroblasts, normal spleen cells and various tumor cells. Is lethal for various species of reptiles, amphibian, birds and mammals. Induces smooth muscle contraction. It binds sphingomyelin and induces hemolysis in the same manner as lysenin-related protein 2, and is 10 times more effective than lysenin-related protein 1.<ref>PMID:10684578</ref> <ref>PMID:12676961</ref> <ref>PMID:15274631</ref> <ref>PMID:16971770</ref> <ref>PMID:9210594</ref> <ref>PMID:9478988</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pore-forming proteins insert from solution into membranes to create lesions, undergoing a structural rearrangement often accompanied by oligomerization. Lysenin, a pore-forming toxin from the earthworm Eisenia fetida, specifically interacts with sphingomyelin (SM) and may confer innate immunity against parasites by attacking their membranes to form pores. SM has important roles in cell membranes and lysenin is a popular SM-labeling reagent. The structure of lysenin suggests common ancestry with other pore-forming proteins from a diverse set of eukaryotes and prokaryotes. The complex with SM shows the mode of its recognition by a protein in which both the phosphocholine headgroup and one acyl tail are specifically bound. Lipid interaction studies and assays using viable target cells confirm the functional reliance of lysenin on this form of SM recognition.
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{{STRUCTURE_3zxg| PDB=3zxg | SCENE= }}
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Structures of lysenin reveal a shared evolutionary origin for pore-forming proteins and its mode of sphingomyelin recognition.,De Colibus L, Sonnen AF, Morris KJ, Siebert CA, Abrusci P, Plitzko J, Hodnik V, Leippe M, Volpi E, Anderluh G, Gilbert RJ Structure. 2012 Sep 5;20(9):1498-507. Epub 2012 Jul 19. PMID:22819216<ref>PMID:22819216</ref>
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===lysenin sphingomyelin complex===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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{{ABSTRACT_PUBMED_22819216}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[3zxg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Eisenia_fetida Eisenia fetida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZXG OCA].
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</StructureSection>
[[Category: Eisenia fetida]]
[[Category: Eisenia fetida]]
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[[Category: Abrusci, P.]]
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[[Category: Abrusci, P]]
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[[Category: Anderluh, G.]]
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[[Category: Anderluh, G]]
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[[Category: Colibus, L De.]]
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[[Category: Colibus, L De]]
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[[Category: Gilbert, R J.C.]]
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[[Category: Gilbert, R J.C]]
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[[Category: Hodnik, V.]]
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[[Category: Hodnik, V]]
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[[Category: Leippe, M.]]
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[[Category: Leippe, M]]
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[[Category: Morris, K J.]]
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[[Category: Morris, K J]]
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[[Category: Plitzko, J.]]
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[[Category: Plitzko, J]]
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[[Category: Siebert, C A.]]
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[[Category: Siebert, C A]]
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[[Category: Sonnen, A F.P.]]
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[[Category: Sonnen, A F.P]]
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[[Category: Volpi, E.]]
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[[Category: Volpi, E]]
[[Category: Earthworm]]
[[Category: Earthworm]]
[[Category: Pore-forming toxin]]
[[Category: Pore-forming toxin]]
[[Category: Toxin]]
[[Category: Toxin]]

Revision as of 01:26, 25 December 2014

lysenin sphingomyelin complex

3zxg, resolution 3.12Å

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