4j5u
From Proteopedia
(Difference between revisions)
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| - | + | ==X-ray crystal structure of a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith== | |
| - | + | <StructureSection load='4j5u' size='340' side='right' caption='[[4j5u]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4j5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rickettsia_rickettsii_str._'sheila_smith' Rickettsia rickettsii str. 'sheila smith']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J5U FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">glyA, A1G_06305 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=392021 Rickettsia rickettsii str. 'Sheila Smith'])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j5u RCSB], [http://www.ebi.ac.uk/pdbsum/4j5u PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLYA_RICRS GLYA_RICRS]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051] | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Serine hydroxymethyltransferase|Serine hydroxymethyltransferase]] |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Glycine hydroxymethyltransferase]] | [[Category: Glycine hydroxymethyltransferase]] | ||
[[Category: Rickettsia rickettsii str. 'sheila smith']] | [[Category: Rickettsia rickettsii str. 'sheila smith']] | ||
| - | [[Category: | + | [[Category: Structural genomic]] |
[[Category: National institute of allergy and infectious disease]] | [[Category: National institute of allergy and infectious disease]] | ||
[[Category: Niaid]] | [[Category: Niaid]] | ||
| - | [[Category: Seattle structural genomics center for infectious disease]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 01:30, 25 December 2014
X-ray crystal structure of a serine hydroxymethyltransferase with covalently bound PLP from Rickettsia rickettsii str. Sheila Smith
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