4v7r
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(New page: ==Yeast 80S ribosome.== <StructureSection load='4v7r' size='340' side='right' caption='4v7r, resolution 4.00Å' scene=''> == Structural highlights == <table><tr><td...)
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Revision as of 01:42, 25 December 2014
proteopedia linkproteopedia linkYeast 80S ribosome.
Structural highlights
Function[RL4A_YEAST] Participates in the regulation of the accumulation of its own mRNA.[1] [RL5_YEAST] Binds 5S RNA and is required for 60S subunit assembly. [GBLP_YEAST] Located at the head of the 40S ribosomal subunit in the vicinity of the mRNA exit channel, it serves as a scaffold protein that can recruit other proteins to the ribosome. Involved in the negative regulation of translation of a specific subset of proteins.[2] [RS9B_YEAST] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.[3] [RS15_YEAST] Involved in the nuclear export of the small ribosomal subunit. Has a role in the late stage of the assembly of pre-40S particles within the nucleus and controls their export to the cytoplasm.[4] [RS19A_YEAST] Required for proper maturation of the small (40S) ribosomal subunit. Binds to 40s pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA.[5] [6] [RL25_YEAST] This protein binds to a specific region on the 26S rRNA. [RLA0_YEAST] Ribosomal protein P0 is the functional equivalent of E.coli protein L10. [RSSA1_YEAST] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.[7] [8] [RL37A_YEAST] Binds to the 23S rRNA (By similarity). [RL11A_YEAST] Binds to 5S ribosomal RNA. [RS9A_YEAST] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.[9] [RS2_YEAST] Important in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.[10] [RS14A_YEAST] Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.[11] Publication Abstract from PubMedCrystal structures of prokaryotic ribosomes have described in detail the universally conserved core of the translation mechanism. However, many facets of the translation process in eukaryotes are not shared with prokaryotes. The crystal structure of the yeast 80S ribosome determined at 4.15 angstrom resolution reveals the higher complexity of eukaryotic ribosomes, which are 40% larger than their bacterial counterparts. Our model shows how eukaryote-specific elements considerably expand the network of interactions within the ribosome and provides insights into eukaryote-specific features of protein synthesis. Our crystals capture the ribosome in the ratcheted state, which is essential for translocation of mRNA and transfer RNA (tRNA), and in which the small ribosomal subunit has rotated with respect to the large subunit. We describe the conformational changes in both ribosomal subunits that are involved in ratcheting and their implications in coordination between the two associated subunits and in mRNA and tRNA translocation. Crystal structure of the eukaryotic ribosome.,Ben-Shem A, Jenner L, Yusupova G, Yusupov M Science. 2010 Nov 26;330(6008):1203-9. PMID:21109664[12] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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