2auc
From Proteopedia
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| - | [[Image:2auc.gif|left|200px]] | + | [[Image:2auc.gif|left|200px]] |
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| - | '''Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor''' | + | {{Structure |
| + | |PDB= 2auc |SIZE=350|CAPTION= <scene name='initialview01'>2auc</scene>, resolution 2.60Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2AUC is a [ | + | 2AUC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_knowlesi Plasmodium knowlesi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor., Bosch J, Turley S, Daly TM, Bogh SM, Villasmil ML, Roach C, Zhou N, Morrisey JM, Vaidya AB, Bergman LW, Hol WG, Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4852-7. Epub 2006 Mar 17. PMID:[http:// | + | Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor., Bosch J, Turley S, Daly TM, Bogh SM, Villasmil ML, Roach C, Zhou N, Morrisey JM, Vaidya AB, Bergman LW, Hol WG, Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4852-7. Epub 2006 Mar 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16547135 16547135] |
[[Category: Plasmodium knowlesi]] | [[Category: Plasmodium knowlesi]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: psi]] | [[Category: psi]] | ||
[[Category: sgpp]] | [[Category: sgpp]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
[[Category: structural genomics of pathogenic protozoa consortium]] | [[Category: structural genomics of pathogenic protozoa consortium]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:53:56 2008'' |
Revision as of 13:53, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor
Overview
The causative agents of malaria have developed a sophisticated machinery for entering multiple cell types in the human and insect hosts. In this machinery, a critical interaction occurs between the unusual myosin motor MyoA and the MyoA-tail Interacting Protein (MTIP). Here we present one crystal structure that shows three different conformations of Plasmodium MTIP, one of these in complex with the MyoA-tail, which reveal major conformational changes in the C-terminal domain of MTIP upon binding the MyoA-tail helix, thereby creating several hydrophobic pockets in MTIP that are the recipients of key hydrophobic side chains of MyoA. Because we also show that the MyoA helix is able to block parasite growth, this provides avenues for designing antimalarials.
About this Structure
2AUC is a Protein complex structure of sequences from Plasmodium knowlesi. Full crystallographic information is available from OCA.
Reference
Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor., Bosch J, Turley S, Daly TM, Bogh SM, Villasmil ML, Roach C, Zhou N, Morrisey JM, Vaidya AB, Bergman LW, Hol WG, Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4852-7. Epub 2006 Mar 17. PMID:16547135
Page seeded by OCA on Thu Mar 20 15:53:56 2008
Categories: Plasmodium knowlesi | Protein complex | Bosch, J. | Hol, W G.J. | SGPP, Structural Genomics of Pathogenic Protozoa Consortium. | Turley, S. | Myoa | Myoa tail interacting protein | Myosin a-tail | Protein structure initiative mtip | Psi | Sgpp | Structural genomic | Structural genomics of pathogenic protozoa consortium
