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3ara
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ara FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ara OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ara RCSB], [http://www.ebi.ac.uk/pdbsum/3ara PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ara FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ara OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ara RCSB], [http://www.ebi.ac.uk/pdbsum/3ara PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DUT_HUMAN DUT_HUMAN]] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.<ref>PMID:8805593</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: DUTP diphosphatase]] | [[Category: DUTP diphosphatase]] | ||
| - | [[Category: Chong, K T | + | [[Category: Chong, K T]] |
| - | [[Category: Fukuoka, M | + | [[Category: Fukuoka, M]] |
| - | [[Category: Miyahara, S | + | [[Category: Miyahara, S]] |
| - | [[Category: Miyakoshi, H | + | [[Category: Miyakoshi, H]] |
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Magnesium binding]] | [[Category: Magnesium binding]] | ||
Revision as of 01:49, 25 December 2014
Discovery of Novel Uracil Derivatives as Potent Human dUTPase Inhibitors
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