3tnf
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3tnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._philadelphia_1 Legionella pneumophila subsp. pneumophila str. philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TNF FirstGlance]. <br> | <table><tr><td colspan='2'>[[3tnf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._philadelphia_1 Legionella pneumophila subsp. pneumophila str. philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TNF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TNF FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qbt|3qbt]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qbt|3qbt]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MEL, RAB8, RAB8A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), lida, lpg0940 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 Legionella pneumophila subsp. pneumophila str. Philadelphia 1])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MEL, RAB8, RAB8A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), lida, lpg0940 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 Legionella pneumophila subsp. pneumophila str. Philadelphia 1])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tnf RCSB], [http://www.ebi.ac.uk/pdbsum/3tnf PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tnf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tnf RCSB], [http://www.ebi.ac.uk/pdbsum/3tnf PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RAB8A_HUMAN RAB8A_HUMAN]] May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization.<ref>PMID:20890297</ref> <ref>PMID:21282656</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Protein LidA from Legionella is a Rab GTPase supereffector.,Schoebel S, Cichy AL, Goody RS, Itzen A Proc Natl Acad Sci U S A. 2011 Oct 19. PMID:22011575<ref>PMID:22011575</ref> | Protein LidA from Legionella is a Rab GTPase supereffector.,Schoebel S, Cichy AL, Goody RS, Itzen A Proc Natl Acad Sci U S A. 2011 Oct 19. PMID:22011575<ref>PMID:22011575</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Legionella pneumophila subsp. pneumophila str. philadelphia 1]] | [[Category: Legionella pneumophila subsp. pneumophila str. philadelphia 1]] | ||
| - | [[Category: Cichy, A L | + | [[Category: Cichy, A L]] |
| - | [[Category: Goody, R S | + | [[Category: Goody, R S]] |
| - | [[Category: Itzen, A | + | [[Category: Itzen, A]] |
| - | [[Category: Schoebel, S | + | [[Category: Schoebel, S]] |
[[Category: Drra]] | [[Category: Drra]] | ||
[[Category: Er]] | [[Category: Er]] | ||
Revision as of 01:52, 25 December 2014
LidA from Legionella in complex with active Rab8a
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Categories: Homo sapiens | Legionella pneumophila subsp. pneumophila str. philadelphia 1 | Cichy, A L | Goody, R S | Itzen, A | Schoebel, S | Drra | Er | Gdp/gtp binding rab-binding | Golgi | Gtpase | Lcv | Legionella pneumophila | Plasmamembrane | Protein transport | Rab-effector | Rab8a | Sidm | Vesicle recuitment | Vesicular trafficking | Vesicular transport
