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4bd8
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bd8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bd8 RCSB], [http://www.ebi.ac.uk/pdbsum/4bd8 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bd8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bd8 RCSB], [http://www.ebi.ac.uk/pdbsum/4bd8 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 01:54, 25 December 2014
Bax domain swapped dimer induced by BimBH3 with CHAPS
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