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4kk2
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure== | |
| - | + | <StructureSection load='4kk2' size='340' side='right' caption='[[4kk2]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[4kk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Artemisia_spiciformis Artemisia spiciformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KK2 FirstGlance]. <br> |
| + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDS-5, FDS-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=235357 Artemisia spiciformis])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kk2 RCSB], [http://www.ebi.ac.uk/pdbsum/4kk2 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/CHRDS_ARTSI CHRDS_ARTSI]] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.<ref>PMID:12782626</ref> | [[http://www.uniprot.org/uniprot/CHRDS_ARTSI CHRDS_ARTSI]] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.<ref>PMID:12782626</ref> | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | ||
| - | <references | + | |
[[Category: Artemisia spiciformis]] | [[Category: Artemisia spiciformis]] | ||
| - | [[Category: Almo, S C | + | [[Category: Almo, S C]] |
| - | [[Category: Bhosle, R | + | [[Category: Bhosle, R]] |
| - | [[Category: Chowdhury, S | + | [[Category: Chowdhury, S]] |
| - | [[Category: Evans, B | + | [[Category: Evans, B]] |
| - | [[Category: Gerlt, J A | + | [[Category: Gerlt, J A]] |
| - | [[Category: Glenn, A Scott | + | [[Category: Glenn, A Scott]] |
| - | [[Category: Hammonds, J | + | [[Category: Hammonds, J]] |
| - | [[Category: Hillerich, B | + | [[Category: Hillerich, B]] |
| - | [[Category: Imker, H J | + | [[Category: Imker, H J]] |
| - | [[Category: Initiative, Enzyme Function | + | [[Category: Initiative, Enzyme Function]] |
| - | [[Category: Love, J | + | [[Category: Love, J]] |
| - | [[Category: Obaidi, N F.Al | + | [[Category: Obaidi, N F.Al]] |
| - | [[Category: Poulter, C D | + | [[Category: Poulter, C D]] |
| - | [[Category: Seidel, R D | + | [[Category: Seidel, R D]] |
| - | [[Category: Toro, R | + | [[Category: Toro, R]] |
| - | [[Category: Vetting, M W | + | [[Category: Vetting, M W]] |
| - | [[Category: Washington, E | + | [[Category: Washington, E]] |
[[Category: Enzyme function initiative]] | [[Category: Enzyme function initiative]] | ||
[[Category: Isoprenoid synthase]] | [[Category: Isoprenoid synthase]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 01:55, 25 December 2014
Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure
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Categories: Artemisia spiciformis | Almo, S C | Bhosle, R | Chowdhury, S | Evans, B | Gerlt, J A | Glenn, A Scott | Hammonds, J | Hillerich, B | Imker, H J | Initiative, Enzyme Function | Love, J | Obaidi, N F.Al | Poulter, C D | Seidel, R D | Toro, R | Vetting, M W | Washington, E | Enzyme function initiative | Isoprenoid synthase | Structural genomic | Transferase
