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2wcb
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wcb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wcb RCSB], [http://www.ebi.ac.uk/pdbsum/2wcb PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wcb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wcb RCSB], [http://www.ebi.ac.uk/pdbsum/2wcb PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/S10AC_HUMAN S10AC_HUMAN]] S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.<ref>PMID:11522286</ref> <ref>PMID:17208591</ref> <ref>PMID:18292089</ref> <ref>PMID:19386136</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Blagova, E V | + | [[Category: Blagova, E V]] |
| - | [[Category: Bronstein, I B | + | [[Category: Bronstein, I B]] |
| - | [[Category: Moroz, O V | + | [[Category: Moroz, O V]] |
| - | [[Category: Wilkinson, A J | + | [[Category: Wilkinson, A J]] |
| - | [[Category: Wilson, K S | + | [[Category: Wilson, K S]] |
[[Category: Calcium signalling]] | [[Category: Calcium signalling]] | ||
[[Category: Host-parasite response]] | [[Category: Host-parasite response]] | ||
[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
Revision as of 02:06, 25 December 2014
S100A12 COMPLEX WITH ZINC IN THE ABSENCE OF CALCIUM
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