4is1
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==Crystal structure of ZNF217 bound to DNA== | |
| - | + | <StructureSection load='4is1' size='340' side='right' caption='[[4is1]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4is1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IS1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f2j|4f2j]]</td></tr> | |
| - | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZNF217, ZABC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4is1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4is1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4is1 RCSB], [http://www.ebi.ac.uk/pdbsum/4is1 PDBsum]</span></td></tr> |
| - | [[4is1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IS1 OCA]. | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ZN217_HUMAN ZN217_HUMAN]] Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.<ref>PMID:16203743</ref> <ref>PMID:17259635</ref> <ref>PMID:18625718</ref> <ref>PMID:16940172</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Guss, J M | + | [[Category: Guss, J M]] |
| - | [[Category: Jacques, D A | + | [[Category: Jacques, D A]] |
| - | [[Category: Mackay, J P | + | [[Category: Mackay, J P]] |
| - | [[Category: Vandevenne, M S | + | [[Category: Vandevenne, M S]] |
[[Category: Metal binding protein-dna complex]] | [[Category: Metal binding protein-dna complex]] | ||
[[Category: Transcription factor]] | [[Category: Transcription factor]] | ||
[[Category: Zinc finger]] | [[Category: Zinc finger]] | ||
Revision as of 02:14, 25 December 2014
Crystal structure of ZNF217 bound to DNA
| |||||||||||
