2az2

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[[Image:2az2.gif|left|200px]]<br /><applet load="2az2" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2az2.gif|left|200px]]
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caption="2az2, resolution 2.60&Aring;" />
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'''Flock House virus B2-dsRNA Complex (P4122)'''<br />
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{{Structure
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|PDB= 2az2 |SIZE=350|CAPTION= <scene name='initialview01'>2az2</scene>, resolution 2.60&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY=
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|GENE= B2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12287 Flock house virus])
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}}
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'''Flock House virus B2-dsRNA Complex (P4122)'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2AZ2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Flock_house_virus Flock house virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZ2 OCA].
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2AZ2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Flock_house_virus Flock house virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZ2 OCA].
==Reference==
==Reference==
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Dual modes of RNA-silencing suppression by Flock House virus protein B2., Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR, Nat Struct Mol Biol. 2005 Nov;12(11):952-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16228003 16228003]
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Dual modes of RNA-silencing suppression by Flock House virus protein B2., Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR, Nat Struct Mol Biol. 2005 Nov;12(11):952-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16228003 16228003]
[[Category: Flock house virus]]
[[Category: Flock house virus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: protein-rna complex]]
[[Category: protein-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:32:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:55:35 2008''

Revision as of 13:55, 20 March 2008

Image:2az2.gif


PDB ID 2az2

Drag the structure with the mouse to rotate
, resolution 2.60Å
Gene: B2 (Flock house virus)
Coordinates: save as pdb, mmCIF, xml



Flock House virus B2-dsRNA Complex (P4122)


Overview

As a counter-defense against antiviral RNA silencing during infection, the insect Flock House virus (FHV) expresses the silencing suppressor protein B2. Biochemical experiments show that B2 binds to double-stranded RNA (dsRNA) without regard to length and inhibits cleavage of dsRNA by Dicer in vitro. A cocrystal structure reveals that a B2 dimer forms a four-helix bundle that binds to one face of an A-form RNA duplex independently of sequence. These results suggest that B2 blocks both cleavage of the FHV genome by Dicer and incorporation of FHV small interfering RNAs into the RNA-induced silencing complex.

About this Structure

2AZ2 is a Single protein structure of sequence from Flock house virus. Full crystallographic information is available from OCA.

Reference

Dual modes of RNA-silencing suppression by Flock House virus protein B2., Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR, Nat Struct Mol Biol. 2005 Nov;12(11):952-7. PMID:16228003

Page seeded by OCA on Thu Mar 20 15:55:35 2008

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