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2az2
From Proteopedia
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| - | [[Image:2az2.gif|left|200px]] | + | [[Image:2az2.gif|left|200px]] |
| - | + | ||
| - | '''Flock House virus B2-dsRNA Complex (P4122)''' | + | {{Structure |
| + | |PDB= 2az2 |SIZE=350|CAPTION= <scene name='initialview01'>2az2</scene>, resolution 2.60Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= B2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12287 Flock house virus]) | ||
| + | }} | ||
| + | |||
| + | '''Flock House virus B2-dsRNA Complex (P4122)''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2AZ2 is a [ | + | 2AZ2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Flock_house_virus Flock house virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZ2 OCA]. |
==Reference== | ==Reference== | ||
| - | Dual modes of RNA-silencing suppression by Flock House virus protein B2., Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR, Nat Struct Mol Biol. 2005 Nov;12(11):952-7. PMID:[http:// | + | Dual modes of RNA-silencing suppression by Flock House virus protein B2., Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR, Nat Struct Mol Biol. 2005 Nov;12(11):952-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16228003 16228003] |
[[Category: Flock house virus]] | [[Category: Flock house virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: protein-rna complex]] | [[Category: protein-rna complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:55:35 2008'' |
Revision as of 13:55, 20 March 2008
| |||||||
| , resolution 2.60Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | B2 (Flock house virus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Flock House virus B2-dsRNA Complex (P4122)
Overview
As a counter-defense against antiviral RNA silencing during infection, the insect Flock House virus (FHV) expresses the silencing suppressor protein B2. Biochemical experiments show that B2 binds to double-stranded RNA (dsRNA) without regard to length and inhibits cleavage of dsRNA by Dicer in vitro. A cocrystal structure reveals that a B2 dimer forms a four-helix bundle that binds to one face of an A-form RNA duplex independently of sequence. These results suggest that B2 blocks both cleavage of the FHV genome by Dicer and incorporation of FHV small interfering RNAs into the RNA-induced silencing complex.
About this Structure
2AZ2 is a Single protein structure of sequence from Flock house virus. Full crystallographic information is available from OCA.
Reference
Dual modes of RNA-silencing suppression by Flock House virus protein B2., Chao JA, Lee JH, Chapados BR, Debler EW, Schneemann A, Williamson JR, Nat Struct Mol Biol. 2005 Nov;12(11):952-7. PMID:16228003
Page seeded by OCA on Thu Mar 20 15:55:35 2008
