2b0u

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[[Image:2b0u.gif|left|200px]]<br /><applet load="2b0u" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2b0u.gif|left|200px]]
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caption="2b0u, resolution 2.800&Aring;" />
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'''The Structure of the Follistatin:Activin Complex'''<br />
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{{Structure
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|PDB= 2b0u |SIZE=350|CAPTION= <scene name='initialview01'>2b0u</scene>, resolution 2.800&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=IR3:IRIDIUM+(III)+ION'>IR3</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene> and <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
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|ACTIVITY=
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|GENE= INHBA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), FST ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''The Structure of the Follistatin:Activin Complex'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2B0U is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=IR3:'>IR3</scene>, <scene name='pdbligand=MLI:'>MLI</scene> and <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0U OCA].
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2B0U is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B0U OCA].
==Reference==
==Reference==
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The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding., Thompson TB, Lerch TF, Cook RW, Woodruff TK, Jardetzky TS, Dev Cell. 2005 Oct;9(4):535-43. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16198295 16198295]
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The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding., Thompson TB, Lerch TF, Cook RW, Woodruff TK, Jardetzky TS, Dev Cell. 2005 Oct;9(4):535-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16198295 16198295]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: tgf-beta]]
[[Category: tgf-beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:33:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:56:11 2008''

Revision as of 13:56, 20 March 2008

Image:2b0u.gif


PDB ID 2b0u

Drag the structure with the mouse to rotate
, resolution 2.800Å
Ligands: , and
Gene: INHBA (Homo sapiens), FST (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



The Structure of the Follistatin:Activin Complex


Contents

Overview

TGF-beta ligands stimulate diverse cellular differentiation and growth responses by signaling through type I and II receptors. Ligand antagonists, such as follistatin, block signaling and are essential regulators of physiological responses. Here we report the structure of activin A, a TGF-beta ligand, bound to the high-affinity antagonist follistatin. Two follistatin molecules encircle activin, neutralizing the ligand by burying one-third of its residues and its receptor binding sites. Previous studies have suggested that type I receptor binding would not be blocked by follistatin, but the crystal structure reveals that the follistatin N-terminal domain has an unexpected fold that mimics a universal type I receptor motif and occupies this receptor binding site. The formation of follistatin:BMP:type I receptor complexes can be explained by the stoichiometric and geometric arrangement of the activin:follistatin complex. The mode of ligand binding by follistatin has important implications for its ability to neutralize homo- and heterodimeric ligands of this growth factor family.

Disease

Known disease associated with this structure: Polycystic ovary syndrome OMIM:[136470]

About this Structure

2B0U is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding., Thompson TB, Lerch TF, Cook RW, Woodruff TK, Jardetzky TS, Dev Cell. 2005 Oct;9(4):535-43. PMID:16198295

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