2mto

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mto OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mto RCSB], [http://www.ebi.ac.uk/pdbsum/2mto PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mto OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mto RCSB], [http://www.ebi.ac.uk/pdbsum/2mto PDBsum]</span></td></tr>
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== Function ==
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[[http://www.uniprot.org/uniprot/CXA1A_CONRE CXA1A_CONRE]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. Is a specific blocker of the alpha-9/alpha-10 nAChR. Is also active on alpha-7 (but 1000-fold less potent) and on alpha-2/beta-2, alpha-2/beta-4, alpha-3/beta-4, alpha-3/beta-2, alpha-4/beta-2, alpha-4/beta-4 and alpha-6 or -3/beta-2 or -3 (but 2000-fold less potent) channels.<ref>PMID:16445293</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 02:30, 25 December 2014

Non-reducible analogues of alpha-conotoxin RgIA: [2,8]-cis dicarba RgIA

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