3uyp
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3uyp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UYP FirstGlance]. <br> | <table><tr><td colspan='2'>[[3uyp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UYP FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uze|3uze]], [[3uzq|3uzq]], [[3uzv|3uzv]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uze|3uze]], [[3uzq|3uzq]], [[3uzv|3uzv]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uyp RCSB], [http://www.ebi.ac.uk/pdbsum/3uyp PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uyp RCSB], [http://www.ebi.ac.uk/pdbsum/3uyp PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q9IZJ0_9FLAV Q9IZJ0_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody.,Cockburn JJ, Navarro Sanchez ME, Fretes N, Urvoas A, Staropoli I, Kikuti CM, Coffey LL, Arenzana Seisdedos F, Bedouelle H, Rey FA Structure. 2012 Feb 8;20(2):303-14. Epub 2012 Jan 26. PMID:22285214<ref>PMID:22285214</ref> | Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody.,Cockburn JJ, Navarro Sanchez ME, Fretes N, Urvoas A, Staropoli I, Kikuti CM, Coffey LL, Arenzana Seisdedos F, Bedouelle H, Rey FA Structure. 2012 Feb 8;20(2):303-14. Epub 2012 Jan 26. PMID:22285214<ref>PMID:22285214</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Dengue virus 4]] | [[Category: Dengue virus 4]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Bedouelle, H | + | [[Category: Bedouelle, H]] |
| - | [[Category: Cockburn, J J.B | + | [[Category: Cockburn, J J.B]] |
| - | [[Category: Coffey, L L | + | [[Category: Coffey, L L]] |
| - | [[Category: Fretes, N | + | [[Category: Fretes, N]] |
| - | [[Category: Kikuti, C M | + | [[Category: Kikuti, C M]] |
| - | [[Category: Rey, F A | + | [[Category: Rey, F A]] |
| - | [[Category: Sanchez, M E.Navarro | + | [[Category: Sanchez, M E.Navarro]] |
| - | [[Category: Seisdedos, F Arenzana | + | [[Category: Seisdedos, F Arenzana]] |
| - | [[Category: Staropoli, I | + | [[Category: Staropoli, I]] |
| - | [[Category: Urvoas, A | + | [[Category: Urvoas, A]] |
[[Category: Dengue antibody neutralization]] | [[Category: Dengue antibody neutralization]] | ||
[[Category: Immune system]] | [[Category: Immune system]] | ||
Revision as of 02:39, 25 December 2014
Crystal structure of the dengue virus serotype 4 envelope protein domain III in complex with the variable domains of Mab 4E11
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